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Approccio globale alla Prevenzione e alla Cura del Dolore del Neonato, Bambino e Adolescente
A breve saranno aperte le iscrizioni al Corso di Perfezionamento in ‘Approccio globale alla Prevenzione e alla Cura del Dolore del Neonato, Bambino e Adolescente’, nato per offrire ai Pediatri un programma educativo di un grande valore scientifico e morale, e dal quale si potranno ottenere 9 crediti ECM. Il corso si terrà a Siena dal 16 al 19 marzo 2023


Prof.ssa Anna Maria Aloisi

Prof. Carlo Valerio Bellieni



Tel: +393473579228


Partecipa alla spedizione Annamaria Aloisi, Università di Siena, Biomedicine and Nutrition Network of Research, Biomedicina e Nutrizione


About The Health & Nutrition Summit

 In its 7th year and held over 3 days, the 2023 Health & Nutrition Summit brings together exciting world-renowned speakers, rich content, networking opportunities and access to top experts in the health and wellness field, all in a stunning location – Peppers Noosa Resort & Villas in Noosa QLD.

Food and Nutrition

About Conference


ConferenceSeries LLC  invite all  the  speakers, dietitian, nutritionists, nutrition science researchers, experts, experimenters, officials, moderators,  researchers, exhibitors  and  students  to join the 4th International conference on  food  and  nutrition  which  will be conducted on April 06-07, 2023 at Madrid, Spain. The event welcomes all researchers to take part in this conference on food and  nutrition. This conference is to  “Gain  your  powers  and  strengths  with the   knowledge  on  food and  nutrition  to   achieve  your  goals  and  also through  this,  we can  protect  our  planet”.


Pain study in X-linked adrenoleukodystrophy in males and females

Valeria Bachiocco¹, Marco Cappa², Anna Petroni¹³, Ettore Salsano⁴, Carla Bizzarri², Ilaria Ceccarelli¹, Gabriele Cevenini⁵, Viviana Pensato⁴ and Anna Maria Aloisi¹³

1 University of Siena, Department of Medicine, Surgery and Neuroscience, Siena, Italy; 

2 Bambino Gesù Children’s Hospital, IRCCS Rome, Italy

3 Biomedicine and Nutrition Research Network, Via Paracelso 1, 20129 Milan, Italy

4 Neurological Institute Carlo Besta, IRCCS Milan, Italy

5 University of Siena, Department of Medical Biotechnology, Siena, Italy


X-linked adrenoleukodystrophy (ALD) is a metabolic disorder in which very long chain fatty acids (VLCFAs) are accumulated in the nervous system and adrenal cortex, impairing their functions. Three main variants are described in males: adrenomyeloneuropathy (AMN), a cerebral form (cALD or cAMN) and Addison disease only (AD), while for females no classification is used. Chronic pain occurrence and sensory phenotype profile were assessed in 30 patients (20 males: 10 AMN, 1 cAMN, 1 cALD, 8 AD, and 10 females). A set of instruments assessed the intensity, quality and extent of pain, while a battery of Quantitative Sensory Testing (QST) procedures examined the functional status of Ab and Ad fibers. Principal component analysis and hierarchical clustering with sensory responses input were used to identify distinct clusters.

Nearly half of the subjects reported pain, with high prevalence in females and male AMN patients. No sex differences in pain dimensions were found. The sensory responses were heterogeneous, differing among the clinical variants and between genders. Male AMN/cAMN/cALD patients showed the worst impairment. Ab and Ad fibers were affected in males and females, but Ab fibers appeared undamaged in females when tactile sensitivity was tested. Abnormal responses were localized in the lower body district, according to the dying-back pattern of the neuropathy. Cluster analysis showed discrete clusters for each function examined, with well-interpretable sensory and clinical phenotypes. The study of pain and of the sensory profile appears to indicate a difference in the mechanisms underlying the AMN/cAMN /cALD and AD clinical forms and in the treatment of the respective generated pains.